TERAPIA DO COÁGULO SANGUÍNEO AUTÓLOGO NA CICATRIZAÇÃO DE LESÕES: REVISÃO DE ESCOPO
DOI:
https://doi.org/10.31011/reaid-2023-v.97-n.3-art.1760Palavras-chave:
Cicatrização, Ferimentos e Lesões, Terapêutica, Revisão, EnfermagemResumo
Objetivo: Mapear e sumarizar evidências científicas sobre a terapia do coágulo sanguíneo autólogo na cicatrização das lesões. Método: Trata-se de uma revisão de escopo construída em cinco etapas, realizada nas bases/motores de busca Biblioteca Virtual em Saúde (BVS), PubMed, Google Acadêmico, Biblioteca Scientific Electronic Library Online (SCIELO) e no Portal de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os descritores controlados foram “cicatrização” e “ferimentos e lesões” e o não controlado Terapia do Coágulo Sanguíneo Autólogo”, com suas derivações em inglês e espanhol. Foram incluídos artigos publicados nos últimos 10 anos, e excluídos os duplicados ou que não estivessem disponíveis na íntegra. Para a extração foi construído um quadro sinóptico e os dados foram analisados de forma descritiva. Resultados: Foram identificadas 246 publicações e a amostra final foi composta por 16 publicações. O ano de 2022 foi o que apresentou maior número de publicações (5;33,4%), 15(93,7%) estudos estavam em inglês e 12(75,0%) em revistas dos Estados Unidos. Não foram localizados estudos no Brasil sobre o tema. Verificou-se que 11(68,7%) estudos avaliaram o efeito da terapia, dos quais 6(37,5%) tiveram delineamento quase-experimental, três (18,7%) foram estudo de caso e dois (12,5%) estudo de série de casos. Conclusões: O artigo atingiu os objetivos ao mapear as evidências científicas sobre a temática, demostrando que a terapia possui boa efetividade no tratamento de lesões por pressão. Contudo, há limitações pela falta de pesquisas com métodos com maior nível de evidência e com amostras maiores.
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Jesus MAP, Pires PS, Biondo CS, Matos RM. Incidência de lesão por pressão em pacientes internados e fatores de risco associados. Rev Baiana Enferm [Internet]. 2020 [citado 2023 Jan 15]; 34: e36587. DOI: https://doi.org/10.18471/rbe.v34.36587 DOI: https://doi.org/10.18471/rbe.v34.36587
National Pressure Ulcer Advisory Panel (NPUAP). Consenso NPUAP 2016 - Classificação das lesões por pressão adaptado culturalmente para o Brasil. SOBEST/SODENDE [Internet]. 2020 [citado 2023 Jan 15]. Disponível em: https://sobest.com.br/wp-content/uploads/2020/10/CONSENSO-NPUAP-2016_traducao-SOBEST-SOBENDE.pdf.
Edsberg LE, Black JM, Goldberg M, McNichol L, Moore L, Sieggreen M. Revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System. J Wound Ostomy Continence Nurs [Internet]. 2016 [citado 2023 Fev 04]; 43(6): 585-97. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098472/pdf/wocn-43-585.pdf. DOI: https://doi.org/10.1097/WON.0000000000000281
Agência Nacional de Vigilância Sanitária. Nota técnica GVIMS/GGTES nº 03/2017 – Práticas seguras para prevenção de lesão por pressão em serviços de saúde [Internet]. Brasília, DF: ANVISA; 2017 [citado 2023 Jan 15]. Disponível em: https://docs.google.com/viewerng/viewer?url=https://www.ccih.med.br/wp-content/uploads/2017/10/les%C3%A3o-por-press%C3%A3o.pdf&hl=pt_BR.
Ministério da Saúde (BR). Manual do Pé Diabético, estratégias para o cuidado da pessoa com doença crônica [Internet]. Brasília, DF: MS; 2016 [citado 2023 Fev 04]. Disponível em: http://www.as.saude.ms.gov.br/wp-content/uploads/2016/06/manual_do_pe_diabetico.pdf.
Miranda TCF, Santos GS, Chaves JN, Azevedo RF. Ozonioterapia para o tratamento complementar da úlcera do pé diabético: revisão integrativa. Rev Enferm Contemp [Internet]. 2022 [citado 2023 Fev 06]; 11: e 4647. Doi: http://dx.doi.org/10.17267/2317-3378rec.2022.e4647. DOI: https://doi.org/10.17267/2317-3378rec.2022.e4647
Dimitriou E. Chronic vênus ulcer reduction and full recovery by na auyologous blood clot: A case study. Journal of Clinical Images and Medical Case Reports [Internet]. 2022 [citado 2023 Jan 15]; 3(3):1714. Available from: https://jcimcr.org/pdfs/JCIMCR-v3-1714.pdf.
Williams M, Davidson D, Wahab N, Hawkins J, Wachuku CD, Snyder R. Innovative treatment utilizing an autologous blood clot for diabetic foot ulcers. Wounds. [Internet]. 2022 [citado 2023 Fev 12] Jul;34(7):195-200. Doi: 10.25270/wnds/21089. PMID: 35881826.
Peters MD, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews.JBI Evidence Implementation [Internet]. 2015 Sept [cited 2021 Out 27]; 13(3):141-46. Available from: https://journals.lww.com/ijebh/Fulltext/2015/09000/Guidance_for_conducting_systematic_scoping_reviews.5.aspxdoi: http://dx.doi.org/10.1097/XEB.0000000000000050. DOI: https://doi.org/10.1097/XEB.0000000000000050
Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z (Editors). JBI [Internet]. 2020 [cited 2023 Fev 02]; Available from: https://synthesismanual.jbi.global https://doi.org/10.46658/JBIMES-20-12. DOI: https://doi.org/10.46658/JBIRM-20-01
Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Latino Am Enfermagem [Internet]. 2007 [cited 2015 Apr 02]; 15(3): 508-11. Available from: http://www.scielo.br/pdf/rlae/v15n3/v15n3a23.pdf DOI: https://doi.org/10.1590/S0104-11692007000300023
Tricco AC, Lillie E, Zarin W, O'brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467-73. DOI: https://doi.org/10.7326/M18-0850
Kushnir I, Kushnir A, Serena TE, Garfinkel D. Efficacy and Safety of a Novel Autologous Wound Matrix in the Management of Complicated, Chronic Wounds: A Pilot Study. Wounds: a compendium of clin res practice [Internet]. 2016 [cited 2021 Out 25];28(9):317-27, Available from: https://pubmed.ncbi.nlm.nih.gov/27701127/
Snyder RJ, Kasper MA, Patel K, Carter MJ, Kushni I, Kushnir A, et al. Safety and Efficacy of an Autologous Blood Clot Product in the Management of Texas 1A or 2A Neuropathic Diabetic Foot Ulcers: A Prospective, Multicenter, Open Label Pilot Study. Wounds: a compendium of clin res practice [Internet]. 2018 [cited 2023 Fev 05]; 30(7):84-9. Available from: https://pubmed.ncbi.nlm.nih.gov/29718812/
Vallejo L, Achterberg J. Uso de una matriz autóloga en el tratamiento de úlceras de pie diabético, con espectroscopia de infrarrojo cercano y medidor de pH dérmico. J Wound Care [Internet]. 2020 [cited 2021 Out 24]; 29(sup 3): 24-31. DOI: https://doi.org/10.12968/jowc.2020.29.LatAm_sup_3.24 DOI: https://doi.org/10.12968/jowc.2020.29.LatAm_sup_3.24
Snyder RJ, Schultz, G, Wachuku, C, Rashid, AM, Ead, JKK. Proposed Mechanism of Action of Topically Applied Autologous Blood Clot Tissue: A Quintessential Cellular and Tissue Based Therapy. J American Podiatric Medical Association [Internet]. 2020 [cited 2023 Fev 27]; DOI: https://doi.org/10.7547/20-140 DOI: https://doi.org/10.7547/20-140
Snyder RJ, Ead K. A Comparative Analysis of the Cost Effectiveness of Five Advanced Skin Substitutes in the Treatment of Foot Ulcers in Patients with Diabetes. Ann Rev Resear [Internet]. 2020 [cited 2023 Fev 25]; 6(1): 555678. DOI: https://doi.org/10.19080/ARR.2020.06.555678 DOI: https://doi.org/10.19080/ARR.2020.06.555678
Naude L, Idensohn P, Bruwer F, Balenda G, Gurevich M, Mulder M, et al. An observational pilot study to collect safety and efficacy data on wound care using whole blood clot technology on hard-to-heal wounds. Wounds International [Internet]. 2021 [cited 2023 Fev 15];12(2). Available from: https://www.woundsinternational.com/journals/issue/644/article-details/observational-pilot-study-collect-safety-and-efficacy-data-wound-care-using-whole-blood-clot-technology-hard-heal-wounds
Curtis RD, Chinenye D W. Utilization of ActiGraft, an Autologous (Blood Clot) Graft in the Reconstruction of Soft Tissue Deficit from Hand Trauma – A Case Study. Ann Rev Resear [Internet]. 2021 [cited 2023 Fev 15]; 6(4): 555692. DOI: https://doi.org/10.19080/ARR.2021 DOI: https://doi.org/10.19080/ARR.2021.06.555692
Emre O, Chinenye W M. The Use of ActiGraft, an Autologous Skin Graft, in the Treatment of Complex Diabetes Foot Ulcer - A Case Study. Ann Rev Resear [Internet]. 2021. [cited 2023 Fev 04]; 6(2): 555685. DOI: https://doi.org/10.19080/ARR.2021.06.555685 DOI: https://doi.org/10.19080/ARR.2021.06.555685
Gurevich M, Wahab N, Wachuku C, Ead KJ, Snyder RJ. ActiGraft Treatment in Complex Wounds with Exposed Structure - A Case Series. Ann Rev Resear [Internet]. 2021 [cited 2023 Fev 16]; 7(1): 555701. DOI: https://doi.org-10.19080/ARR.2021.07.555701 DOI: https://doi.org/10.19080/ARR.2021.07.555701
Landau Z, Whitacre KL, Leewood C, Hawkins J, Wachuku C.Utilization of a topical autologous blood clot for treatment of pressure ulcers. Intern Wound J [Internet]. 2022. [cited 2023 Fev 17]; DOI: https://doi.org/10.1111/iwj.13927 DOI: https://doi.org/10.1111/iwj.13927
Williams M, Davidson D, Wahab N, Hawkins J, Wachuku CD, Snyder R. Innovative treatment utilizing an autologous blood clot for diabetic foot ulcers. Wounds: a Compendium of Clin Res Practice [Internet]. 2022. [cited 2023 Fev 15];34(7):195-200. DOI: https://doi.org/10.25270/wnds/21104 DOI: https://doi.org/10.25270/wnds/21089
Dimitriou E. Chronic venus ulcer pain reduction and full recovery by an autologous blood clot: A case study. J Clin Images Med Case Res [Internet]. 2022 [cited 2023 Fev 14]; 3(3):1714. Available from: https://jcimcr.org/pdfs/JCIMCR-v3-1714.pdf DOI: https://doi.org/10.52768/2766-7820/1714
Snyder RJ, Driver V, Cole W, Joseph WS, Reyzelman A, Lantis JC, et al. Topical autologous blood clot therapy: an introduction and development of consensus panel to guide use in the treatment of complex wound types. Wounds: a Compendium Clin Res Practice [Internet]. 2022 [cited 2023 Fev 14];34(9):223-8. DOI: https://doi.org/110.25270/wnds/22011 DOI: https://doi.org/10.25270/wnds/22011
Naude L, Balenda G, Lombaard A. Autologous whole blood clot and negative-pressure wound therapy in South Africa: A comparison of the cost and social considerations. South African Medical J [Internet]. 2022 [cited 2023 Fev 15]; 112(1): 800-5. Available from: https://samajournals.co.za/index.php/samj/article/view/262
Gurevich M, Heinz SM, Fridman R, Hawkins J, Wachuku CD. Use of autologous whole blood clot in the treatment of complex surgical wounds: a case series. J wound care north American Supplement [Internet]. 2023 [cited 2023 Fev 14]; 329(2). DOI: https://doi.org/10.12968/jowc.2023.32.Sup2.S4 DOI: https://doi.org/10.12968/jowc.2023.32.Sup2.S4
Snyder RJ, Driver V, Cole W, Joseph WS, Reyzekman A, Lantis JC, et al. Topical autologous blood clot therapy: consensus panel recommendations to guide use in the treatment of complex wound types. Wounds [Internet]. 2023 [cited 2023 Fev 27]; 35(1):1. DOI: https://doi.org/10.25270/wnds/22061 DOI: https://doi.org/10.25270/wnds/22061
Aitken SJ, Choy OS, Monaro S. A qualitative study exploring patient concerns and values in chronic limb-threatening ischemia. J Surg Res [Internet]. [cited 2023 Fev 14]; 2019;243:289-300. DOI: https://doi.org/10.1016/j.jss.2019.05.055 DOI: https://doi.org/10.1016/j.jss.2019.05.055
Boersema GC, Smart H, Cilliers MGC, Mulder M, Weir GR, Bruwer FA, et al. Management of nonhealable and maintenancewounds: A systematic integrative review and referral pathway. Adv Skin Wound Care [Internet]. 2021 [cited 2023 Fev 24]; 34(1):11-22. DOI: https://doi.org/10.1097/01.ASW.0000722740.93179.9f DOI: https://doi.org/10.1097/01.ASW.0000722740.93179.9f
Olsson M, Jarbrink K, Divakar U, Bajpai R, Upton Z, Schimdtchen A, et al. The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair Regen [Internet]. 2019 [cited 2023 Fev 24]; 27(1):114-125. DOI: https://doi.org/10.1111/wrr.12683 DOI: https://doi.org/10.1111/wrr.12683
Gupta S, Sagar S, Maheshwari G, Kisaka T, Tripathi S. Chronic wounds: Magnitude, socioeconomic burden and consequences. Wounds Asia [Internet]. 2021 [cited 2023 Fev 27]; 4:8-14. Available from: https://www.woundsasia.com/journals/issue/640/article-details/chronic-wounds-magnitude-socioeconomic-burden-and-consequences-english.
Salama SE, Eldeeb AE, Elbarbary AH, Abdelghany SE. Adjuvant hyperbaric oxygen therapy enhances healing of nonischemic diabetic foot ulcers compared with standard wound care alone. Intern j lower extremity wounds [Internet]. 2019 [cited 2023 Fev 25]; 18(1):75-80. DOI: https://doi.org/10.1177/1534734619829939 DOI: https://doi.org/10.1177/1534734619829939
Didomenico LA, Orgill DP, Galiano RD, Serena TE, Carter MJ, Kaufman JP, et al. Aseptically processed placental membrane improves healing of diabetic foot ulcerations: prospective, randomized clinical trial. Plastic and Reconstructive Surgery Global Open. [Internet]. 2016. [cited 2023 Fev 25]; 4(10). DOI: https://doi.org/10.1097/GOX.0000000000001095 DOI: https://doi.org/10.1097/GOX.0000000000001095
Naude L, Balenda, G, Lombaard, A. Autologous whole blood clot and negative-pressure wound therapy in South Africa: A comparison of the cost and social considerations. South African Medical J [Internet]. 2022. [cited 2023 Fev 26]; 1129(10): 800-5. DOI: https://doi.org/10.7196/SAMJ.2022.v112i10.16527 DOI: https://doi.org/10.7196/SAMJ.2022.v112i10.16527
Guest JF, Fuller GW, Vowden P. Cohort study evaluating the burden of wounds to the UK’s National Health Service in 2017/2018: Update from 2012/2013. BMJ Open [Internet]. 2020 [cited 2023 Fev 18]; 10(12): e045253. DOI: https://doi.org/10.1136/ bmjopen-2020-045253 DOI: https://doi.org/10.1136/bmjopen-2020-045253
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